Notre Dame vs. Louisville spread, odds, line, props: College football

Jimmie Kaylor has unveiled his Week 6 college football selections, top wagers, and prognosis for the showdown between Louisville and Notre Dame this Saturday.

Ranked No. 10, the Notre Dame Fighting Irish (5-1) are determined to maintain their College Football Playoff aspirations as they embark on an away game against the No. 25 Louisville Cardinals. Following a heart-wrenching defeat to Ohio State in Week 4, the Irish rebounded with a 21-14 victory over Duke in Week 5. Meanwhile, the Cardinals seek to preserve their unblemished record after narrowly clinching a 13-10 win against N.C. State last week. Their previous encounter in 2020 saw the Irish emerge victorious with a score of 12-7.

The action is set to kick off at Cardinal Stadium at 7:37 p.m. ET. According to the SportsLine consensus, the Irish are favored by 6.5 points in the latest Notre Dame vs. Louisville odds, with an over/under of 53.5 points. Before placing any bets or making picks for the Louisville vs. Notre Dame game, it’s advisable to consult the insights and wagering advice of SportsLine football expert Jimmie Kaylor.

Kaylor, an NFL, college football, and DFS authority at SportsLine, boasts nearly a decade of experience covering the NFL and college football as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player affords him a distinctive viewpoint in shaping his fantasy lineups and finalizing his betting selections.

Kaylor’s football selections for SportsLine have been scorching, tallying an impressive 9-1 record last week and a perfect 4-0 in the Notre Dame vs. Duke match-up, elevating his season record to an outstanding 18-3 on his premier bets in 2023. Those who have followed his picks are enjoying considerable success.

Presently, he has turned his attention towards the clash between Notre Dame and Louisville, finalizing his selections and college football prognoses. For Kaylor’s picks, visit SportsLine. Below, you’ll find various college football odds and wagering lines for the Notre Dame vs. Louisville match-up:

  • Notre Dame vs. Louisville spread: Notre Dame -6.5
  • Notre Dame vs. Louisville over/under: 53.5 points
  • Notre Dame vs. Louisville money line: Notre Dame -249, Louisville +203

Key Stats:

  • ND: Quarterback Sam Hartman boasts an impressive 14 touchdown passes in 2023.
  • LOU: Louisville maintains an average of 494.8 total offensive yards per game.

For the Notre Dame vs. Louisville picks, consult SportsLine. Access the live stream of the game on fubo (available for a free trial).

Why Notre Dame Could Cover:

Notre Dame is poised to extend their remarkable winning streak in regular season encounters against ACC opponents to 31. Head Coach Marcus Freeman’s defensive strategies have been instrumental, with the team conceding a mere 12.5 points and allowing just 271 total offensive yards per game.

On the offensive front, transfer quarterback Sam Hartman, alongside running back Audric Estime, have been pivotal. Hartman enters this face-off with an impressive record of 1,458 passing yards, 14 touchdowns, and zero interceptions. He has also notched two rushing touchdowns. Over the course of his career, Hartman stands as the seventh-highest in passing touchdowns (124) and ninth-highest in passing yards (14,425). Estime brings in an average of 7.1 yards per carry, accumulating 672 rushing yards and seven touchdowns this season.

Why Louisville Could Cover:

Under the leadership of first-year head coach Jeff Brohm, the Cardinals exude confidence. They step into this match-up with an impeccable record and have secured a top-25 spot in the national coaches poll for the first time since 2020. A victory here would mark their best start since the 2013 season.

Louisville boasts one of the most dynamic players in the ACC in running back Jawhar Jordan. The former Syracuse transfer poses a genuine threat with his explosive runs from the backfield, averaging an impressive 7.7 yards per carry. In the ongoing season, he has amassed 510 rushing yards and six touchdowns, in addition to seven receptions for 159 yards and a receiving touchdown.

For guidance on which team to support, head to SportsLine.

Guidance for Making Picks in the Louisville vs. Notre Dame Matchup

After thorough analysis, Kaylor has scrutinized every aspect of this matchup and is favoring the Under for the point total. He’s also pinpointed a pivotal X-factor that has him fully endorsing one side of the spread. You’ll only find out what it is, and which side to support, by heading over to SportsLine.

Curious about who will emerge victorious in the Notre Dame vs. Louisville clash this Saturday? And what’s the game-changing X-factor that makes one side of the spread a compelling choice? Take a trip to SportsLine now to access the Notre Dame vs. Louisville picks. These insights come from an expert with a decade of experience covering college football, boasting an impressive 18-3 record on his top bets in 2023.


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